TL;DR
This paper presents an analytical framework combining within-host and between-host models to understand SARS-CoV-2 transmission dynamics, linking viral load to infection spread from animal reservoirs to humans.
Contribution
It introduces a comprehensive analytical model that integrates viral life cycle, immune response, and transmission pathways of COVID-19, providing insights into its spread from animal reservoirs to humans.
Findings
Analytical solutions for SARS-CoV-2 transmission dynamics.
Linking viral load to infection spread.
Modeling transmission from animal reservoirs to humans.
Abstract
The present work shows that it is possible to analytically solve a general model to explain the transmission dynamics of SARS-CoV-2. First, the within-host model is described, and later a between-host model, where the coupling between them is the viral load of SARS-CoV-2. The within-host model describes the equations involved in the life cycle of SARS-CoV-2, and also the immune response; while that the between-Host model analyzes the dynamics of virus spread from the original source of contagion associated with bats, subsequently transmitted to a host, and then reaching the reservoir (Huanan Seafood Wholesale Market in Wuhan ), until finally infecting the human population.
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