Novel BCI paradigm for ALS patients based on EEG and Pupillary Accommodative Response

TL;DR

This paper introduces a novel multimodal BCI paradigm combining EEG and pupillary response to improve communication for ALS patients, especially during disease progression to CLIS, by using adaptive neurofeedback training.

Contribution

It presents the first integration of EEG with pupillary accommodative response in a BCI system, enhancing adaptability and reliability for ALS patients transitioning to complete locked-in syndrome.

Findings

Proposes a multimodal BCI combining EEG and PAR signals.

Introduces an adaptive neurofeedback training program.

Aims to support ALS patients through disease progression.

Abstract

Brain-computer interfaces (BCIs) are one of the few alternatives to enable locked-in syndrome (LIS) patients to communicate with the external world, while they are the only solution for complete locked-in syndrome (CLIS) patients, who lost the ability to control eye movements. However, successful usage of endogenous electroencephalogram(EEG)-based BCI applications is often not trivial, due to EEG variations between and within sessions and long user training required. In this work we suggest an approach to deal with this two main limitations of EEG-BCIs by inserting a progressive and expandable neurofeedback training program, able to continuously tailor the classifier to the specific user, into a multimodal BCI paradigm. We propose indeed the integration of EEG with a non-brain signal: the pupillary accommodative response (PAR). The PAR is a change in pupil size associated with gaze shifts from far to close targets; it is not governed by the somatic nervous system and is thus potentially preserved after the evolution from LIS to CLIS, which often occurs in neurodegenerative diseases, such as amyotrophic lateral sclerosis. Multimodal BCIs have been broadly investigated in literature, due to their ability to yield better overall control performances, but this would be the first attempt combining EEG and PAR. In the context of the BciPar4Sla, we are exploiting these two signals, with the aim of developing a more reliable BCI, adaptive to the extent of evolving together with the user's ability to elicit the brain phenomena needed for optimal control, and providing support even in the transition from LIS to CLIS.