On a Quaternary Non-Local Isoperimetric Problem
Stanley Alama, Lia Bronsard, Xinyang Lu, Chong Wang

TL;DR
This paper investigates a two-dimensional quaternary inhibitory system combining interface energy and Coulomb-type interactions, analyzing the limiting behavior of micro-domains and their geometric configurations.
Contribution
It introduces a novel limit analysis for a quaternary system, linking micro-domain geometry with global component distribution in a non-local isoperimetric problem.
Findings
Derived geometrical descriptions of limit configurations.
Identified two energy levels governing local structures and global distributions.
Established a connection between micro-domain shapes and energy minimization.
Abstract
We study a two-dimensional quaternary inhibitory system. This free energy functional combines an interface energy favoring micro-domain growth with a Coulomb-type long range interaction energy which prevents micro-domains from unlimited spreading. Here we consider a limit in which three species are vanishingly small, but interactions are correspondingly large to maintain a nontrivial limit. In this limit two energy levels are distinguished: the highest order limit encodes information on the geometry of local structures as a three-component isoperimetric problem, while the second level describes the spatial distribution of components in global minimizers. Geometrical descriptions of limit configurations are derived.
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Taxonomy
TopicsAdvanced Mathematical Modeling in Engineering · Mathematical Biology Tumor Growth · Cellular Mechanics and Interactions
