Involvement of calcium channels Orai3 in the chemoresistance to cisplatin in non-small cell lung cancer (NSCLC)

TL;DR

This paper demonstrates that Orai3 calcium channels activate AKT signaling, contributing to chemoresistance in non-small cell lung cancer, highlighting a potential target for overcoming drug resistance.

Contribution

It provides new evidence linking Orai3 channels to AKT activation and chemoresistance in NSCLC, expanding understanding of calcium channel roles in cancer.

Findings

Orai3 activates AKT signaling in NSCLC.

Orai3 involvement correlates with chemoresistance.

Calcium dysregulation is crucial for lung cancer development.

Abstract

This is the second part of the previous review. In the previous review we suspected that Orai3 channels were involved in lung cancer and more precisely in several cancers. Here we confirm that calcium dysregulation is important for cancer development. in this paper we show that Orai3 is an upstream activator of AKT and we prove that AKT is involved in chemoresistance in NSCLC.