Low-Dose TOF-PET Based on Surface Electron Production in Dielectric Laminar MCPs

TL;DR

This paper proposes a novel low-dose TOF-PET imaging method using surface electron production in dielectric microchannel plates, eliminating scintillators and photodetectors, enabling safer, cheaper, and more accessible PET scans.

Contribution

The paper introduces a simulation-based approach for direct electron conversion in dielectric MCPs for PET, significantly reducing radiation dose and simplifying scanner design.

Findings

Achieved over 30% conversion efficiency to primary electrons in simulations.

Simulated dose reductions of 100 to 1000 times compared to traditional PET.

Potential for low-cost, portable PET scanners for broader healthcare access.

Abstract

We present simulations of whole-body low-dose time-of-flight positron emission tomography (TOF-PET) based on the direct surface production [1] by 511 keV gamma rays of energetic electrons via the Photo-electric and Compton Effects, eliminating the scintillator and photodetector sub-systems in PET scanners. In Ref. [1] we described Microchannel Plates (MCP) constructed from thin dielectric laminae containing heavy nuclei such as lead or tungsten (LMCP$^{\rm{TM}}$). The laminae surfaces are micro-patterned to form channels, which can then be functionalized to support secondary electron emission in the manner of conventional MCPs. We have simulated direct conversion using modifications to the TOPAS Geant4-based tool kit. A 20 $\times$ 20 $\times$ 2.54 cm$^3$ LMCP, composed of 150-micron thick lead-glass laminae, is predicted to have a $\ge 30$% conversion efficiency to a primary electron that penetrates an interior wall of a pore. The subsequent secondary electron shower is largely confined to one pore and can provide high space and time resolutions. In whole-body PET scanners the technique eliminates the scintillator and photodetector subsystems. The consequent absence of a photocathode allows assembly of large arrays at atmospheric pressure and less stringent vacuum requirements, including use of pumped and cycled systems. TOPAS simulations of the Derenzo and XCAT-brain phantoms are presented with dose reductions of factors of 100 and 1000 from a literature benchmark. New applications of PET at a significantly lower radiation dose include routine screening for early detection of pathologies, the use in diagnostics in previously unserved patient populations such as children, and a larger installed facility base in rural and under-served populations, where simpler gamma detectors and lower radiation doses may enable small low-cost portable PET scanners.