Modelling Spontaneous Firing Activity of the Motor Cortex in a Spiking Neural Network with Random and Local Connectivity

TL;DR

This study presents a spiking neural network model of the motor cortex with local connectivity, demonstrating that realistic connectivity patterns influence firing rates and irregularity, aligning more closely with experimental data and advancing understanding of cortical activity.

Contribution

Introduces a motor cortex model with local connectivity, showing its impact on firing patterns and improving biological plausibility over random connectivity models.

Findings

Local connectivity increased firing rates and distribution variability.

Firing irregularity became more similar to experimental observations.

Connectivity topology significantly influences spontaneous neuronal activity.

Abstract

Computational models of cortical activity provide insight into the mechanisms of higher-order processing in the human brain including planning, perception and the control of movement. Activity in the cortex is ongoing even in the absence of sensory input or discernible movements and is thought to be linked to the topology of cortical circuitry. However, the connectivity and its functional role in the generation of spatio-temporal firing patterns and cortical computations are still unknown. Movement of the body is a key function of the brain, with the motor cortex the main cortical area implicated in the generation of movement. We built a spiking neural network model of the motor cortex which incorporates a laminar structure and circuitry based on a previous cortical model. A local connectivity scheme was implemented to introduce more physiological plausibility to the cortex model, and the effect on the rates, distributions and irregularity of neuronal firing was compared to the original random connectivity method and experimental data. Local connectivity increased the distribution of and overall rate of neuronal firing. It also resulted in the irregularity of firing being more similar to those observed in experimental measurements. The larger variability in dynamical behaviour of the local connectivity model suggests that the topological structure of the connections in neuronal population plays a significant role in firing patterns during spontaneous activity. This model took steps towards replicating the macroscopic network of the motor cortex, replicating realistic spatiotemporal firing to shed light on information coding in the cortex. Large scale computational models such as this one can capture how structure and function relate to observable neuronal firing behaviour, and investigates the underlying computational mechanisms of the brain.