Farthest Streamline Sampling for the Uniform Distribution of Forearm Muscle Fiber Tracts from Diffusion Tensor Imaging

TL;DR

This study introduces Farthest Streamline Sampling (FSS), a novel method for uniformly sampling fiber tracts in forearm muscles using DTI, improving coverage and anatomical accuracy over traditional sampling techniques.

Contribution

FSS is a new filtering approach that enhances uniformity and anatomical correctness of fiber tract sampling in DTI-based muscle analysis.

Findings

FSS achieved higher streamline coverage and lower variation than conventional methods.

FSS reduced sampling of long tracts, aligning with physiological ranges.

Fiber orientations matched cadaveric specimens, validating the method.

Abstract

Background: Diffusion tensor imaging (DTI) has been used to characterize forearm muscle architecture. Since only uniform sampling is performed for seed points rather than fiber tracts, the tracts may be unevenly distributed in the muscle volume. Purpose: To reconstruct uniformly distributed fiber tracts in human forearm by filtering the tracts from DTI. Assessment: Farthest streamline sampling (FSS) was proposed for filtering and compared with two conventional methods, i.e., two-dimensional sampling and three-dimensional sampling. The uniform coverage performance of the methods was evaluated by streamline coverage (SC) and the coefficient of variation of streamline density (SDCV). Architectural parameters were calculated for 17 forearm muscles. Anatomical correctness was verified by 1. visually assessing the fiber orientation, 2. checking whether the architectural parameters were within physiological ranges, and 3. classifying the architectural types. Results: FSS had the highest SC (0.93+0.04) and the lowest SDCV (0.34+0.06) among the three methods (P<0.05). FSS reduced the sampling of long tracts (10% reduction in fiber length, P<0.05), and the architectural parameters were within physiological ranges (two parameters with P<0.05). The fiber orientation of the tractography was visually consistent with that of the cadaveric specimen. The architectural types of 16 muscles were correctly classified, except for the palmaris longus, which had a linear arrangement of fiber endpoints (R2=0.95+0.02, P<0.001). Data Conclusion: FSS reconstructed more muscle regions and uniformly distributed fiber tracts. The tracts were anatomically correct, indicating the validity of fiber tracts. Key Words: diffusion tensor imaging; forearm muscles; architectural properties