A Fluid-Solid-Growth Solver for Cardiovascular Modeling

TL;DR

This paper introduces a comprehensive fluid-solid-growth solver that integrates vascular growth and remodeling into a finite element FSI framework, enabling long-term, patient-specific cardiovascular predictions.

Contribution

It extends existing FSI models by incorporating full 3D constrained mixture theory for vascular growth, allowing for long-term simulations of disease progression.

Findings

Enables long-term predictions of hemodynamics and vessel morphology.

Supports patient-specific modeling for clinical applications.

Increases relevance for studying disease mechanisms.

Abstract

We implement full, three-dimensional constrained mixture theory for vascular growth and remodeling into a finite element fluid-structure interaction (FSI) solver. The resulting "fluid-solid-growth" (FSG) solver allows long term, patient-specific predictions of changing hemodynamics, vessel wall morphology, tissue composition, and material properties. This extension from short term (FSI) to long term (FSG) simulations increases clinical relevance by enabling mechanobioloigcally-dependent studies of disease progression in complex domains.