Diffusion MRI with double diffusion encoding and variable mixing times disentangles water exchange from intrinsic kurtosis

TL;DR

This paper introduces a novel MRI analysis method called μMGE that disentangles water exchange effects from intrinsic kurtosis in diffusion MRI by exploiting their different dependencies on mixing time, enhancing microstructural characterization.

Contribution

The study proposes μMGE, a heuristic signal model that separates exchange and intrinsic kurtosis effects in DDE MRI using multiple mixing times, improving microstructural analysis.

Findings

μMGE can estimate exchange rate and kurtosis components.

Microscopic kurtosis is sensitive to exchange rate.

Distinct signatures of exchange and kurtosis depend on mixing time.

Abstract

Double diffusion encoding (DDE) makes diffusion MRI sensitive to a wide range of microstructural features, and the acquired data can be analysed using different approaches. Correlation tensor imaging (CTI) uses DDE to resolve three components of the diffusional kurtosis: isotropic, anisotropic, and microscopic. The microscopic kurtosis is estimated from the contrast between single diffusion encoding (SDE) and parallel DDE signals at the same b-value. Another approach is multi-Gaussian exchange (MGE), which employs DDE to measure exchange. Sensitivity to exchange is obtained by contrasting SDE and DDE signals at the same b-value. CTI and MGE exploit the same signal contrast to quantify microscopic kurtosis and exchange, and this study investigates the interplay between these two quantities. We perform Monte-Carlo simulations in different geometries with varying levels of exchange and study the behaviour of the parameters from CTI and MGE. We conclude that microscopic kurtosis from CTI is sensitive to the exchange rate and that intercompartmental exchange and the intrinsic kurtosis of individual compartments are distinct sources of microscopic kurtosis. In an attempt to disentangle these two sources, we propose a heuristic signal representation referred to as $\mu$MGE (MGE incorporating intrinsic kurtosis) that accounts for both effects, by exploiting the distinct signatures of exchange and intrinsic kurtosis with varying mixing time: exchange causes a slow dependence of the signal on mixing time while intrinsic kurtosis arguably has a much faster dependence. We find that applying $\mu$MGE to data acquired with multiple mixing times for both parallel and orthogonal DDE may allow estimation of the exchange rate as well as the isotropic, anisotropic, and intrinsic kurtosis.