A Prototype Scintillator Real-Time Beam Monitor for Ultra-high Dose Rate Radiotherapy

TL;DR

This paper presents a prototype scintillator-based real-time beam monitor designed for ultra-high dose rate FLASH radiotherapy, demonstrating high accuracy, radiation tolerance, and rapid data processing suitable for clinical applications.

Contribution

The development of a novel inorganic hybrid scintillator monitor capable of real-time, high-resolution beam analysis and fast beam interruption in FLASH radiotherapy settings.

Findings

Small signal decrease after high cumulative dose exposure

Linear response with respect to dose per pulse

High-resolution 2D beam imaging and rapid data processing

Abstract

FLASH Radiotherapy (RT) is a potentially new cancer radiotherapy technique where an entire therapeutic dose is delivered in about 0.1 s and at ~1000 times higher dose rate than in conventional RT. For clinical trials to be conducted safely, precise and fast beam monitoring that can generate an out-of-tolerance beam interrupt is required. A FLASH Beam Scintillator Monitor (FBSM) is being developed based in part on a novel proprietary inorganic hybrid scintillator material. The FBSM provides large area coverage, low mass profile, linear response over a broad dynamic range, radiation tolerance, and real-time analysis IEC-compliant fast beam-interrupt signal. This paper includes the design concept and test results from a prototype device in radiation beams that include heavy ions, FLASH level dose per pulse electron beams, anda hospital radiotherapy clinic with electron beams. Results include image quality, response linearity, radiation hardness, spatial resolution, and real-time data processing. The scintillator showed a small -0.02%/kGy signal decrease after a 212 kGy cumulative dose resulting from continuous exposure for 15 minutes at a FLASH compatible dose rate of 234 Gy/s. These tests established the linear response of the FBSM with respect to dose per pulse. Comparison with commercial Gafchromic film indicates that the FBSM produces a high resolution 2D beam image and can reproduce a nearly identical beam profile. At 20 kfps or 50 microsec/frame, the real-time FPGA based computation and analysis of beam position, beam shape, and beam dose takes < 1 microsec.