In situ theranostic platform uniting highly localized magnetic fluid hyperthermia, magnetic particle imaging, and thermometry in 3D

TL;DR

This paper presents a novel in situ theranostic platform that integrates magnetic particle imaging, localized magnetic hyperthermia, and thermometry in three dimensions, advancing non-invasive cancer treatment techniques.

Contribution

It introduces the first combined MPI-based imaging, therapy, and thermometry platform in 3D, enabling precise, minimally invasive cancer therapy.

Findings

Successful integration of MPI imaging, hyperthermia, and thermometry in 3D

Demonstrated precise localization and control of hyperthermia

Enhanced safety and efficacy in magnetic fluid therapy

Abstract

In all of medical profession a broad field of research is dedicated to seek less invasive and low-risk forms of therapy with the ultimate goal of non-invasive therapy, particularly in neoplasmic diseases. Theranostic platforms, combining diagnostic and therapeutic approaches within one system, have thus garnered interest to augment invasive surgical, chemical, and ionizing interventions. Magnetic particle imaging (MPI) offers, with its versatile tracer material (superparamagnetic iron oxide nanoparticles, SPIOs), a quite recent alternative to established radiation based diagnostic modalities. In addition, MPI lends a bimodal theranostic frame allowing to combine tomographic imaging with therapy techniques using the very same SPIOs. In this work, we show for the first time the interleaved combination of MPI-based imaging, therapy (highly localized magnetic fluid hyperthermia) and therapy safety control (MPI-based thermometry) within one theranostic platform in all three spatial dimensions.