Mechano-chemical active feedback generates convergence extension in epithelial tissue

TL;DR

This paper introduces a minimal continuum model demonstrating how mechano-chemical feedback can induce spontaneous convergence extension in epithelial tissues, highlighting the role of activity levels and boundary conditions in tissue morphogenesis.

Contribution

It presents a novel 2D viscoelastic active material model linking microscopic biochemistry to tissue-scale convergence extension phenomena.

Findings

Convergence extension occurs beyond a critical activity threshold.

Boundary conditions and substrate coupling control the behavior.

Oscillations and patterns emerge under specific dissipation and elasticity conditions.

Abstract

Convergence extension, the simultaneous elongation of tissue along one axis while narrowing along a perpendicular axis, occurs during embryonic development. A fundamental process that contributes to shaping the organism, it happens in many different species and tissue types. Here we present a minimal continuum model, that can be directly linked to the controlling microscopic biochemistry, which shows spontaneous convergence extension. It is comprised of a 2D viscoelastic active material with a mechano-chemical active feedback mechanism coupled to a substrate via friction. Robust convergent extension behaviour emerges beyond a critical value of the activity parameter and is controlled by the boundary conditions and the coupling to the substrate. Oscillations and spatial patterns emerge in this model when internal dissipation dominates over friction, as well as in the active elastic limit.