Comparative Study of Lycopene Encapsulation Efficiency in Polycapprolactone Vs Poly Lactic Co-glycolic Acid

TL;DR

This study compares the encapsulation efficiency of PCL and PLGA polymers for lycopene, demonstrating that PCL forms smaller, more stable nanoparticles with potential for better controlled release due to its slower degradation rate.

Contribution

It provides a comparative analysis of PCL and PLGA for lycopene encapsulation, highlighting PCL's advantages in nanoparticle size and stability for gastrointestinal delivery.

Findings

PCL nanoparticles are smaller and more stable than PLGA.

PCL has a lower degradation rate, making it suitable for controlled release.

Significant physicochemical differences observed between PCL and PLGA nanoparticles.

Abstract

Lycopene contributes to the red-colored pigmentation of fruits and vegetables, and it is a fat-soluble carotenoid with antioxidant properties. Epidemiological studies have shown the significant health benefits associated to the consumption of lycopene rich foods, because of the anti-cancer properties. Degradative losses of lycopene during processing is a grave concern, hence encapsulation provides a remedy. The objective of this study is to evaluate the encapsulation efficiency of two biodegradable polymers (PLGA and PCL) as for controlled release of lycopene in the gastrointestinal (GI) system. The nanoparticles (NP) were synthesized by emulsion evaporation method and physicochemical properties was determined using a Dynamic Light Scattering spectroscopy. The results show the hydrodynamic diameter of the lycopene NP synthesized in PCL (200 mg) and 3500 mg surfactant and sonicated for 15 min was 79.23+0.85 nm (Lowest). PLGA (500 mg) and 500 mg surfactant with 15 min sonication was observed to have the lowest NP diameter (108.2+2.66 nm) among the others. Significant difference result found in PDI value (0.12+0.07) when PCL of 200mg dissolve in 3500 mg of surfactant. On the other hands the zeta potential values were much smaller in case of PCL NP ranged between -1.3+0.046 and -4.21+0.08 mV compared to the PLGA NP -72.36+2.17 to 107.66+3.15 mV in all experiments. Thus, NP synthesized with PCL and surfactant provide a smaller sized nano-solution than PLGA and surfactant. As the degradation rate for PCL is lower than PLGA so PCL can be considered as a potential biodegradable polymer than PLGA to encapsulate lycopene.