The construction of ceRNAs network reveals the prognostic characteristics of prostate cancer

TL;DR

This study constructs a ceRNAs network to understand its role in prostate cancer progression and prognosis, highlighting potential therapeutic targets based on transcript regulation mechanisms.

Contribution

It provides a comprehensive analysis of ceRNAs regulatory mechanisms in prostate cancer and develops a network with prognostic and therapeutic implications.

Findings

Identified key ceRNAs involved in prostate cancer progression

Constructed a ceRNAs network with potential prognostic value

Suggested ceRNAs as therapeutic targets for prostate cancer

Abstract

The dysregulation of transcripts is characterized as one of the main mechanisms in tumor pathogenesis. The recent discovery developed a new hypothesis, competitive endogenous RNAs (ceRNAs), which could regulate other RNA transcripts via competing for their shared miRNAs. The interaction of elements in ceRNAs network was involved in a large range of biological reactions and facilitate to cancer progression. In this study, we performed a comprehensive investigation on the regulatory mechanisms and functional roles of ceRNAs in prostate cancer (PCa) and constructed a ceRNAs network which could possess potential value in patient prognosis and be evaluated as therapeutic targets for PCa.