Positronium Physics and Biomedical Applications

TL;DR

This paper reviews the fundamental physics of positronium and explores its diverse applications in biomedical imaging, highlighting its potential as a biomarker in medical diagnostics and the implications for understanding matter and biological processes.

Contribution

It provides a comprehensive overview of positronium's role in QED studies, fundamental physics tests, and innovative biomedical imaging techniques, emphasizing new clinical applications.

Findings

Positronium decays are sensitive to molecular and biological structures.

High-sensitivity PET systems enable positronium-based tissue diagnostics.

Positronium imaging offers potential for detecting tissue pathology.

Abstract

Positronium is the simplest bound state, built of an electron and a positron. Studies of positronium in vacuum and its decays in medium tell us about Quantum Electrodynamics, QED, and about the structure of matter and biological processes of living organisms at the nanoscale, respectively. Spectroscopic measurements constrain our understanding of QED bound state theory. Searches for rare decays and measurements of the effect of gravitation on positronium are used to look for new physics phenomena. In biological materials positronium decays are sensitive to the inter- and intra-molecular structure and to the metabolism of living organisms ranging from single cells to human beings. This leads to new ideas of positronium imaging in medicine using the fact that during positron emission tomography (PET) as much as 40% of positron annihilation occurs through the production of positronium atoms inside the patient's body. A new generation of the high sensitivity and multi-photon total-body PET systems opens perspectives for clinical applications of positronium as a biomarker of tissue pathology and the degree of tissue oxidation.