An optimal control problem subject to strong solutions of chemotaxis-consumption models
Francisco Guill\'en-Gonz\'alez, Andr\'e Luiz Corr\^ea Vianna Filho

TL;DR
This paper studies an optimal control problem for a chemotaxis-consumption model, establishing existence, uniqueness, and optimality conditions for strong solutions in a three-dimensional bounded domain.
Contribution
It extends previous weak solution results to strong solutions, proving existence, uniqueness, and deriving first order optimality conditions for the control problem.
Findings
Existence and uniqueness of global strong solutions under regularity conditions.
Existence of a global optimal control solution.
Derivation of first order optimality conditions using Lagrange multipliers.
Abstract
We consider a bilinear optimal control problem associated to the following chemotaxis-consumption model in a bounded domain during a time interval : with , endowed with isolated boundary conditions and initial conditions for , being the cell density, the chemical concentration and the bilinear control acting in a subdomain . The existence of weak solutions to this model given , for some , has been proved in [F. Guill\'en-Gonz\'alez and A. L. Corr\^ea Vianna Filho, Optimal Control Related to Weak Solutions of a Chemotaxis-Consumption Model, arXiv:2211.14612, 2022]. In this paper, we study a related optimal control problem in the…
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Taxonomy
TopicsMathematical Biology Tumor Growth · Phagocytosis and Immune Regulation
