Covariate Adjustment in Experiments with Matched Pairs
Yuehao Bai, Liang Jiang, Joseph P. Romano, Azeem M. Shaikh, Yichong, Zhang

TL;DR
This paper investigates how covariate adjustment affects inference in matched pairs experiments, revealing that fixed effects improve precision while high-dimensional methods like LASSO can offer further gains.
Contribution
It provides a comprehensive analysis of covariate adjustment methods in matched pairs designs, identifying optimal adjustments and demonstrating their effectiveness through theory and simulations.
Findings
Fixed effects for pairs are optimal for finite-dimensional adjustments.
High-dimensional LASSO-based adjustments improve precision under certain conditions.
Simulation confirms theoretical advantages of covariate adjustment methods.
Abstract
This paper studies inference on the average treatment effect in experiments in which treatment status is determined according to "matched pairs" and it is additionally desired to adjust for observed, baseline covariates to gain further precision. By a "matched pairs" design, we mean that units are sampled i.i.d. from the population of interest, paired according to observed, baseline covariates and finally, within each pair, one unit is selected at random for treatment. Importantly, we presume that not all observed, baseline covariates are used in determining treatment assignment. We study a broad class of estimators based on a "doubly robust" moment condition that permits us to study estimators with both finite-dimensional and high-dimensional forms of covariate adjustment. We find that estimators with finite-dimensional, linear adjustments need not lead to improvements in precision…
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Taxonomy
TopicsAdvanced Causal Inference Techniques · Statistical Methods in Clinical Trials · Optimal Experimental Design Methods
