Breathing cluster in complex neuron-astrocyte networks

TL;DR

This paper models neuron-astrocyte networks to investigate how astrocytes influence neural cluster synchronization and spontaneous switching, revealing a breathing cluster phenomenon driven by network symmetry and neuron-astrocyte interactions.

Contribution

It introduces a novel complex neuron-astrocyte network model and provides a theoretical analysis of the mechanisms behind breathing clusters and neural synchronization.

Findings

Breathing clusters switch between synchrony and asynchrony intermittently.

Network symmetry determines cluster contents and stability.

Astrocyte-neuron interactions induce spontaneous state switching.

Abstract

Brain activities are featured by spatially distributed neural clusters of coherent firings and a spontaneous switching of the clusters between the synchrony and asynchrony states. Evidences from {\it in vivo} experiments suggest that astrocytes, a type of glial cell regarded previously as providing only structural and metabolic supports to neurons, participate actively in brain functions and play a crucial role in regulating the neural firing activities, yet the mechanism remains unknown. Introducing astrocyte as a reservoir of the glutamate released from neuron synapses, here we propose the model of complex neuron-astrocyte network and employ it to explore the roles of astrocyte in regulating the synchronization behaviors of networked neurons. It is found that a fraction of neurons on the network can be synchronized as a cluster, while the remaining neurons are kept as desynchronized. Moreover, during the course of network evolution, the cluster is switching between the synchrony and asynchrony states intermittently, henceforth the phenomenon of ``breathing cluster". By the method of symmetry-based analysis, we conduct a theoretical investigation on the stability of the cluster and the mechanism generating the breathing activities. It is revealed that the contents of the cluster are determined by the network symmetry and the breathing activities are due to the interplay between the neural network and the astrocyte. The breathing phenomenon is demonstrated in network models of different structures and neural dynamics. The studies give insights into the cellular mechanism of astrocytes in regulating neural activities, and shed lights onto the spontaneous state switching of the neocortex.