Interpretable Classification of Early Stage Parkinson's Disease from EEG

TL;DR

This paper presents an interpretable machine learning approach using EEG data to detect early-stage Parkinson's Disease, achieving over 80% accuracy and providing insights into relevant brain regions and data types.

Contribution

Introduces a novel EEG representation and interpretable classifiers that effectively identify early Parkinson's, highlighting the significance of N1 sleep data.

Findings

N1 sleep data type has significant predictive power (p < 0.01).

AdaBoost on N1 data achieves over 80% accuracy and recall.

The pipeline outperforms baseline models, enabling meaningful insights.

Abstract

Detecting Parkinson's Disease in its early stages using EEG data presents a significant challenge. This paper introduces a novel approach, representing EEG data as a 15-variate series of bandpower and peak frequency values/coefficients. The hypothesis is that this representation captures essential information from the noisy EEG signal, improving disease detection. Statistical features extracted from this representation are utilised as input for interpretable machine learning models, specifically Decision Tree and AdaBoost classifiers. Our classification pipeline is deployed within our proposed framework which enables high-importance data types and brain regions for classification to be identified. Interestingly, our analysis reveals that while there is no significant regional importance, the N1 sleep data type exhibits statistically significant predictive power (p < 0.01) for early-stage Parkinson's Disease classification. AdaBoost classifiers trained on the N1 data type consistently outperform baseline models, achieving over 80% accuracy and recall. Our classification pipeline statistically significantly outperforms baseline models indicating that the model has acquired useful information. Paired with the interpretability (ability to view feature importance's) of our pipeline this enables us to generate meaningful insights into the classification of early stage Parkinson's with our N1 models. In Future, these models could be deployed in the real world - the results presented in this paper indicate that more than 3 in 4 early-stage Parkinson's cases would be captured with our pipeline.