High-density magnetomyography is superior to high-density surface electromyography for motor unit decomposition: a simulation study

TL;DR

This simulation study demonstrates that high-density magnetomyography (MMG) outperforms high-density surface electromyography (EMG) in identifying individual motor unit discharges, offering a promising non-invasive approach for neuromuscular research.

Contribution

The paper introduces a biophysical simulation comparing MMG and EMG, showing MMG's superior ability to decompose motor units non-invasively.

Findings

MMG increased identifiable motor units by 76%.

MMG detects deeper motor units more effectively.

MMG provides more accurate motor unit discharge patterns.

Abstract

Objective: Studying motor units (MUs) is essential for understanding motor control, the detection of neuromuscular disorders and the control of human-machine interfaces. Individual motor unit firings are currently identified in vivo by decomposing electromyographic (EMG) signals. Due to our body's properties and anatomy, individual motor units can only be separated to a limited extent with surface EMG. Unlike electrical signals, magnetic fields do not interact with human tissues. This physical property and the emerging technology of quantum sensors make magnetomyography (MMG) a highly promising methodology. However, the full potential of MMG to study neuromuscular physiology has not yet been explored. Approach: In this work, we perform in silico trials that combine a biophysical model of EMG and MMG with state-of-the-art algorithms for the decomposition of motor units. This allows the prediction of an upper-bound for the motor unit decomposition accuracy. Main results: It is shown that non-invasive high-density MMG data is superior over comparable high-density surface EMG data for the robust identification of the discharge patterns of individual motor units. Decomposing MMG instead of EMG increased the number of identifiable motor units by 76%. Notably, MMG exhibits a less pronounced bias to detect superficial motor units. Significance: The presented simulations provide insights into methods to study the neuromuscular system non-invasively and in vivo that would not be easily feasible by other means. Hence, this study provides guidance for the development of novel biomedical technologies.