Real-time polarimetry of hyperpolarized $^{13}$C nuclear spins using an atomic magnetometer

TL;DR

This paper presents a non-destructive, real-time method for measuring hyperpolarized $^{13}$C nuclear spins using an atomic magnetometer, enabling improved quality control in magnetic resonance applications.

Contribution

It introduces a novel technique combining a miniaturized $^{87}$Rb vapor magnetometer with a dynamical decoupling sequence for real-time hyperpolarization quantification.

Findings

Successfully measured polarization decay of hyperpolarized pyruvate at Earth's field.

Demonstrated non-destructive, repeated polarization measurements over time.

Potential for real-time quality monitoring of hyperpolarized substances.

Abstract

We introduce a method for non-destructive quantification of nuclear spin polarization, of relevance to hyperpolarized spin tracers widely used in magnetic resonance from spectroscopy to in vivo imaging. In a bias field of around 30 nT we use a high-sensitivity miniaturized $^{87}$Rb vapor magnetometer to measure the field generated by the sample, as it is driven by a windowed dynamical decoupling pulse sequence that both maximizes the nuclear spin lifetime and modulates the polarization for easy detection. We demonstrate the procedure applied to a 0.08 M hyperpolarized [1--$^{13}$C]-pyruvate solution produced by dissolution dynamic nuclear polarization, measuring polarization repeatedly during natural decay at Earth's field. Application to real-time quality monitoring of hyperpolarized substances is discussed.