High-resolution Power Doppler Using Null Subtraction Imaging

TL;DR

This paper introduces null subtraction imaging (NSI), a nonlinear beamforming technique that significantly enhances the spatial resolution of power Doppler ultrasound images, outperforming traditional methods with minimal computational cost increase.

Contribution

The study presents a novel application of NSI with SVD-based clutter filters for high-resolution power Doppler imaging, demonstrating substantial resolution improvements over conventional delay-and-sum methods.

Findings

Up to six-fold resolution improvement with NSI

Achieved 39 micrometer resolvability in microvessel imaging

40% increase in computational cost compared to DAS

Abstract

To improve the spatial resolution of power Doppler (PD) imaging, we explored null subtraction imaging (NSI) as an alternative beamforming technique to delay-and-sum (DAS). NSI is a nonlinear beamforming approach that uses three different apodizations on receive and incoherently sums the beamformed envelopes. NSI uses a null in the beam pattern to improve the lateral resolution, which we apply here for improving PD spatial resolution both with and without contrast microbubbles. In this study, we used NSI with three types of singular value decomposition (SVD)-based clutter filters and noise equalization to generate high-resolution PD images. An element sensitivity correction scheme was also proposed as a crucial component of NSI-based PD imaging. First, a microbubble trace experiment was performed to evaluate the resolution improvement of NSI-based PD over traditional DAS-based PD. Then, both contrast-enhanced and contrast free ultrasound PD images were generated from the scan of a rat brain. The cross-sectional profile of the microbubble traces and microvessels were plotted. FWHM was also estimated to provide a quantitative metric. Furthermore, iso-frequency curves were calculated to provide a resolution evaluation metric over the global field of view. Up to six-fold resolution improvement was demonstrated by the FWHM estimate and four-fold resolution improvement was demonstrated by the iso-frequency curve from the NSI-based PD microvessel images compared to microvessel images generated by traditional DAS-based beamforming. A resolvability of 39 um was measured from the NSI-based PD microvessel image. The computational cost of NSI-based PD was only increased by 40 percent over the DAS-based PD.