On the fractional transversely isotropic functionally graded nature of soft biological tissues

TL;DR

This study models the anisotropic poroelastic behavior of meniscal tissue using a fractional Darcy's law, validated through various experimental data, revealing directional differences in fluid flow and elastic properties.

Contribution

It introduces a 3D fractional poroelastic model for meniscal tissue that accurately captures its anisotropic behavior and validates it against multiple experimental datasets.

Findings

Meniscal tissue exhibits transversely isotropic poroelastic behavior.

Fluid flow is significantly faster in the circumferential direction.

The model accurately predicts fluid flux and tissue response.

Abstract

This paper focuses on the origin of the poroelastic anisotropic behaviour of the meniscal tissue and its spatially varying properties. We present confined compression creep test results on samples extracted from three parts of the tissue (Central body, Anterior horn and Posterior horn) in three orientations (Circumferential, Radial and Vertical). We show that a poroelastic model in which the fluid flow evolution is ruled by non-integer order operators (fractional Darcy's law) provides accurate agreement with the experimental creep data. The model is validated against two additional sets of experimental data: stress relaxation and fluid loss during the consolidation process measured as weight reduction. Results show that the meniscus can be considered as a transversely isotropic poroelastic material. This behaviour is due to the fluid flow rate being about three times higher in the circumferential direction than in the radial and vertical directions in the body region of the meniscus. In the anterior horn, the elastic properties are transversely isotropic, with the aggregate modulus higher in the radial direction than in the circumferential and vertical directions. The 3D fractional poroelastic model is implemented in finite element software and quantities such as flux of interstitial fluid during the consolidation process, a non-trivial experimental measure, are determined.