Proton FLASH irradiation platform for small animal setup at Chang Gung Memorial Hospital
Tung-Yuan Hsiao, Lu-Kai Wang, Tzung-Yuang Chen, Ching-Fang Yu, Pan,, Cheng-Ya, Chun-Chieh Wang, Chien-Yu Lin, I-Chun Cho, Huan Niu, and Chien-Hsu, Chen

TL;DR
This paper presents the development of a proton FLASH irradiation platform for small animals at Chang Gung Memorial Hospital, including a real-time dose monitoring system and imaging guidance, enabling advanced radiobiological research.
Contribution
The study introduces a novel experimental station with a real-time dose monitoring system and imaging guidance for small animal proton FLASH irradiation.
Findings
Dose monitoring system achieves 1 ms time resolution.
Maximum dose per pulse is approximately 20 Gy at 100 Gy/s.
Platform facilitates precise small animal irradiation experiments.
Abstract
Background : Proton flash therapy is an emergency research topic in radiation therapy since the Varian announced the promising results from the first in human clinical trial of Flash therapy recently. However, it still needs a lot of researches on this topic, not only to understand the mechanism of the radiobiological effects but also to develop an appropriate dose monitoring system. Purpose : In this study we setup an experimental station for small animal proton Flash irradiation in a clinical machine. The dose monitoring system is able to provide real-time irradiation dose and irradiation time structure. Methods : The dose monitoring system includes homebrewed transmission ionization chamber (TIC), plastic scintillator based beam position monitor, and Poor Man Faraday Cup (FC). Both TIC and FC are equipped with a homebrewed fast reading current integral electronics device. The…
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Taxonomy
TopicsRadiation Therapy and Dosimetry
