Some reflections on the test-negative design
Ronald Meester, Jan Bonte
TL;DR
This paper critically examines the limitations and challenges of using the test-negative design for evaluating COVID-19 vaccines, highlighting philosophical, methodological, and practical issues.
Contribution
It provides a detailed critique of the test-negative design, emphasizing its constraints and potential biases in vaccine effectiveness studies.
Findings
Identifies key philosophical issues affecting the design.
Highlights methodological limitations and biases.
Discusses practical challenges in implementation.
Abstract
We discuss some philosophical, methodological and practical problems concerning the use of the test-negative design for COVID-19 vaccines. These problems limit the use of this design considerably.
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Taxonomy
TopicsSARS-CoV-2 and COVID-19 Research · Vaccine Coverage and Hesitancy