In vitro evaluation of a novel Mg-Sn-Ge ternary alloy for orthopedic applications

TL;DR

This study evaluates a new Mg-Sn-Ge alloy's mechanical, degradation, and biocompatibility properties for orthopedic use, highlighting Mg-2Sn-3Ge as a promising biodegradable material with favorable biological responses.

Contribution

The paper introduces a novel Mg-Sn-Ge alloy with enhanced properties and demonstrates its potential for biodegradable orthopedic applications through comprehensive in vitro testing.

Findings

Mg-2Sn-3Ge alloy shows outstanding biodegradability

Higher Ge content improves hardness and elastic modulus

Most alloys exhibit good biocompatibility except Mg-2Sn-2Ge

Abstract

Magnesium (Mg) and its alloys have attracted considerable attention owing to their excellent biodegradable properties and biocompatibility. Novel Mg-Sn-Ge ternary Mg alloys were developed as potential biodegradable materials for orthopedic applications because of their alloying elements naturally present in humans. The feasibility of these alloys was investigated in terms of mechanical properties, degradation, cytocompatibility, and hemocompatibility. The hardness and elastic modulus of Mg-2Sn-xGe alloys were improved significantly by increasing the Ge content. Among all the alloys, the Mg-2Sn-3Ge alloy displays outstanding biodegradable properties, as evidenced by the electrochemical tests and hydrogen evolution. The degradation products detected on the corroded alloy surfaces weaken at higher Ge levels. The in vitro cytotoxicity assay and hemolysis test showed that the Mg-2Sn-xGe alloys exhibit favorable biocompatibility and hemocompatibility, except for the Mg-2Sn-2Ge alloy.