The sub-diffusive behavior of chromatin in changing environment
Yevgeni Sh. Mamasakhlisov, Vladimir V. Papoyan
TL;DR
This paper introduces a rotor-router walk model to describe the sub-diffusive movement of chromatin double-strand breaks caused by external factors and explores the repair mechanism within this framework.
Contribution
It presents a novel rotor-router walk model to simulate chromatin break dynamics and repair processes under external stress.
Findings
The model captures sub-diffusive behavior of chromatin breaks.
It provides insights into the repair mechanism of double-strand breaks.
The approach links external factors to chromatin dynamics.
Abstract
The rotor-router walk model is proposed to describe the sub-diffusive behavior of double-strand breaks in chromatin caused by external factors such as heavy ions, -irradiation, etc. The mechanism of the double-strand breaks reparation is considered in terms of this model.
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Taxonomy
TopicsDNA and Nucleic Acid Chemistry · Genomics and Chromatin Dynamics · RNA and protein synthesis mechanisms