How flexibility can enhance catalysis

TL;DR

This paper presents a theoretical model demonstrating how conformational flexibility in enzymes can overcome catalytic limitations, potentially guiding the design of more effective artificial catalysts.

Contribution

It introduces a minimal, general model showing how substrate-induced conformational changes can enable barrier-free catalysis, highlighting the importance of flexibility.

Findings

Rigid catalysts are limited in their catalytic ability.

Conformational changes induced by substrate binding can enable barrier-free catalysis.

The model aligns with features of proteins and explains enzyme superiority.

Abstract

Conformational changes are observed in many enzymes, but their role in catalysis is highly controversial. Here we present a theoretical model that illustrates how rigid catalysts can be fundamentally limited and how a conformational change induced by substrate binding can overcome this limitation, ultimately enabling barrier-free catalysis. The model is deliberately minimal, but the principle it illustrates is general and consistent with unique features of proteins as well as with previous informal proposals to explain the superiority of enzymes over other classes of catalysts. Implementing the discriminative switch suggested by the model could help overcome limitations currently encountered in the design of artificial catalysts.