Resolution enhancement of NMR by decoupling with low-rank Hankel model

TL;DR

This paper presents a novel low-rank Hankel model-based method for broadband heteronuclear decoupling in NMR spectroscopy, improving spectral resolution without additional acquisition time.

Contribution

It introduces a new decoupling approach leveraging prior knowledge of coupling values and the Hankel property, enhancing resolution and sensitivity in NMR spectra.

Findings

Effective resolution enhancement demonstrated on synthetic spectra

Maintains sensitivity and suppresses artefacts

Compatible with non-uniform sampling for further improvements

Abstract

Nuclear magnetic resonance (NMR) spectroscopy has become a formidable tool for biochemistry and medicine. Although J-coupling carries essential structural information it may also limit the spectral resolution. Homonuclear decoupling remains a challenging problem. In this work, we introduce a new approach that uses a specific coupling value as prior knowledge, and Hankel property of exponential NMR signal to achieve the broadband heteronuclear decoupling using the low-rank method. Our results on synthetic and realistic HMQC spectra demonstrate that the proposed method not only effectively enhances resolution by decoupling, but also maintains sensitivity and suppresses spectral artefacts. The approach can be combined with the non-uniform sampling, which means that the resolution can be further improved without any extra acquisition time