Simulation of Particle Release for Diffusing Alpha-Emitters Radiation Therapy
Dmytro Fedorchenko, Shlomi Alani
TL;DR
This paper uses Monte Carlo simulations to analyze the release of radium-224 decay products from DART seeds and assesses the resulting radiation dose to tissue, providing insights into safety and efficacy.
Contribution
It introduces a simulation-based approach to quantify daughter nuclei release and dose distribution in DART, which is novel for this therapy.
Findings
Polonium-216 desorption probability is 15%.
Lead-212 desorption probability is 12%.
Dose to tissue exceeds 2.9 Gy for 111 kBq radium-224.
Abstract
We used Monte Carlo simulations to study release of radium-224 daughter nuclei from the seed used for Diffusing Alpha-Emitters Radiation Therapy (DART). Calculated desorption probabilities for polonium-216 (15%) and lead-212 (12%) show that they make a significant contribution to total release from the seed. We also showed that the dose to tissue from decays inside the 10mm long seed exceeds 2.9 Gy for initial radium-224 activity of 111 kBq.
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Taxonomy
TopicsMedical Imaging Techniques and Applications · Advanced Radiotherapy Techniques · Radiopharmaceutical Chemistry and Applications