Evaluation of the Antibacterial and Wound Healing Properties of a Burn Ointment Containing Curcumin, Honey, and Potassium Aluminium

TL;DR

This study evaluates a new burn ointment containing curcumin, honey, and potassium alum, demonstrating significant wound healing and antimicrobial effects in rat models, suggesting it as a promising topical treatment for burns.

Contribution

The paper introduces a novel burn ointment combining curcumin, honey, and potassium alum, showing enhanced healing and antimicrobial properties in experimental models.

Findings

Significant wound healing observed macroscopically and microscopically.

Curcumin and honey exhibit strong antimicrobial effects without cytotoxicity.

The ointment accelerates burn wound re-epithelization in rats.

Abstract

Burn wounds can severely trouble the health system and life quality of patients. The present study aimed to analyze the synergistic healing properties of curcumin, honey, and potassium alum substances merged in a newly-devised burn ointment on second-degree burn wounds in rats. The MIC and MBC tests on 200 clinical isolates of Pseudomonas aeruginous are compared to imipenem in vitro. Their killing time and cytotoxicity are also studied using a standard isolate of P. aeruginous, fibroblast stem cells (FSC) and mouse embryonic fibroblasts (MEF). Furthermore, histopathological and histomorphological assessments are conducted on 150 male Wistar rats whitin four experimental groups to evaluate the efficiency of the prepared burn ointment. We found a significant wound healing in both macroscopical observations and microscopical evaluations. Both curcumin and honey show strong antimicrobial effects with no cytotoxicity. Also, the histopathological results present a considerable and comparable wound re-epithelization in the a group of rats treated with both honey and curcumin after 7 days. The burn ointment containing curcumin, honey, and potassium alum show considerable efficacy in accelerating the healing of experimentally-induced burn wounds in animals. Th novel onement product is propose as a powerful alternative for the topical treatment of burn injuries.