Novel transfer learning schemes based on Siamese networks and synthetic data

TL;DR

This paper introduces a novel transfer learning approach using a Twin-VAE architecture trained on both real and synthetic data, specifically tailored for biotechnology applications with limited labeled data and domain differences.

Contribution

It extends the Twin-VAE architecture with a new training procedure for transfer learning, handling domain shifts and synthetic data integration in biomedical image analysis.

Findings

Outperforms state-of-the-art transfer learning methods in biomedical image processing.

Effective with limited training data and reduced training times.

Demonstrates robustness across different microscopy technologies.

Abstract

Transfer learning schemes based on deep networks which have been trained on huge image corpora offer state-of-the-art technologies in computer vision. Here, supervised and semi-supervised approaches constitute efficient technologies which work well with comparably small data sets. Yet, such applications are currently restricted to application domains where suitable deepnetwork models are readily available. In this contribution, we address an important application area in the domain of biotechnology, the automatic analysis of CHO-K1 suspension growth in microfluidic single-cell cultivation, where data characteristics are very dissimilar to existing domains and trained deep networks cannot easily be adapted by classical transfer learning. We propose a novel transfer learning scheme which expands a recently introduced Twin-VAE architecture, which is trained on realistic and synthetic data, and we modify its specialized training procedure to the transfer learning domain. In the specific domain, often only few to no labels exist and annotations are costly. We investigate a novel transfer learning strategy, which incorporates a simultaneous retraining on natural and synthetic data using an invariant shared representation as well as suitable target variables, while it learns to handle unseen data from a different microscopy tech nology. We show the superiority of the variation of our Twin-VAE architecture over the state-of-the-art transfer learning methodology in image processing as well as classical image processing technologies, which persists, even with strongly shortened training times and leads to satisfactory results in this domain. The source code is available at https://github.com/dstallmann/transfer_learning_twinvae, works cross-platform, is open-source and free (MIT licensed) software. We make the data sets available at https://pub.uni-bielefeld.de/record/2960030.