Microvalve-Based Tunability of Electrically Driven Ion Transport Through a Microfluidic System with Ion-Exchange Membrane

TL;DR

This paper introduces a microvalve-integrated microfluidic system with an ion-exchange membrane that allows dynamic, localized control of ion transport, enabling advanced functionalities like multiplex sensing and biofouling suppression in lab-on-a-chip devices.

Contribution

The study presents a novel microvalve-based approach to actively tune ion transport through an ion-exchange membrane within microfluidic channels, enhancing device functionality.

Findings

Microvalves enable local control of ion transport in microfluidic systems.

Dynamic tuning allows for multiple ICP layers and molecule preconcentration.

The system can suppress biofouling and improve multiplex sensing.

Abstract

Microfluidic channels with embedded ion permselective medium under the application of electric current are commonly used for electrokinetic processes as on-chip ion concentration polarization (ICP) and bioparticle preconcentration to enhance biosensing. Herein, we demonstrate the ability to dynamically control the electrically driven ion transport by integrating individually addressable microvalves. The microvalves are located along a main microchannel that is uniformly coated with a thin layer of an ion-exchange membrane (IEM). The interplay of ionic transport between the solution within the microchannel and the thin IEM, under an applied electric current, can be locally tuned by the deformation of the microvalve. This tunability provides a robust and simple means of implementing new functionalities into lab-on-a-chip devices, e.g., dynamic control over multiple ICP layers and their associated preconcentrated molecule plugs, multiplex sensing, suppression of biofouling as well as plug dispersion, while maintaining the well-known application of microvalves as steric filtration.