Time-frequency analysis of event-related brain recordings: Connecting power of evoked potential and inter-trial coherence

TL;DR

This paper establishes a theoretical and empirical relationship between three key measures in time-frequency analysis of brain recordings, enhancing understanding of evoked brain rhythms and refining neuroscientific analysis tools.

Contribution

It derives a novel theoretical relationship connecting POWavg, ITC, and avgAMP, validated through simulations and real data analysis.

Findings

POWavg and ITC are approximately related by POWavg ≈ avgAMP² × ITC².

Derived exact expressions for the relationship using the S-transform.

Confirmed the theoretical relationship with experimental brain recording data.

Abstract

Objective. In neuroscience, time-frequency analysis has been used to get insight into brain rhythms from brain recordings. In event-related protocols, one applies it to investigate how the brain responds to a stimulation repeated over many trials. In this framework, three measures have been considered: the amplitude of the transform for each single trial averaged across trials, avgAMP; inter-trial phase coherence, ITC; and the power of the evoked potential transform, POWavg. These three measures are sensitive to different aspects of event-related responses, ITC and POWavg sharing a common sensitivity to phase resetting phenomena. Methods. In the present manuscript, we further investigated the connection between ITC and POWavg using theoretical calculations, a simulation study and analysis of experimental data. Results. We derived exact expressions for the relationship between POWavg and ITC in the particular case of the S-transform of an oscillatory signal. In the more general case, we showed that POWavg and ITC are connected through a relationship that roughly reads $\mathrm{POWavg} \approx \mathrm{avgAMP}^2 \times \mathrm{ITC}^2$. This result was confirmed on simulations. We finally compared the theoretical prediction with results from real data. Conclusion. We showed that POWavg and ITC are related through an approximate, simple relationship that also involves avgAMP. Significance. The presented relationship between POWavg, ITC, and avgAMP confirms previous empirical evidence and provides a novel perspective to investigate evoked brain rhythms. It may provide a significant refinement to the neuroscientific toolbox for studying evoked oscillations.