Accurate control to run and stop chemical reactions via relaxation oscillators

TL;DR

This paper presents a method using relaxation oscillators to precisely control the activation and deactivation of multiple chemical reaction modules, enabling automated regulation in molecular computation systems.

Contribution

It introduces a novel oscillator-based approach for chemical reaction regulation, allowing automatic control without physical compartmentalization or manual intervention.

Findings

Successful simulation of oscillator-based regulation of three modules

Equations can be translated into chemical reaction networks

Demonstrates potential for automated chemical reaction control

Abstract

Regulation of multiple reaction modules is quite common in molecular computation and deep learning networks construction through chemical reactions, as is always a headache for that sequential execution of modules goes against the intrinsically parallel nature of chemical reactions. Precisely switching multiple reaction modules both on and off acts as the core role in programming chemical reaction systems. Unlike setting up physical compartments or adding human intervention signals, we adopt the idea of chemical oscillators based on relaxation oscillation, and assign corresponding clock signal components into the modules that need to be regulated. This paper mainly demonstrates the design process of oscillators under the regulation task of three modules, and provides a suitable approach for automatic termination of the modules cycle. We provide the simulation results at the level of ordinary differential equation and ensure that equations can be translated into corresponding chemical reaction networks.