On the number of nucleoproteins in the assembly of coronaviruses: Consequences for COVID-19

TL;DR

This paper reviews the role and quantity of nucleoproteins in coronavirus assembly, highlighting their impact on immune response and regulation, with implications for COVID-19 understanding and treatment.

Contribution

It provides a summarized analysis of experimental data on coronavirus nucleoproteins, emphasizing their significance in viral assembly and immune interactions.

Findings

Nucleoproteins are crucial for virion assembly.

They induce autoimmune responses.

Binding to host RNA influences cellular regulation.

Abstract

The multifunctional nucleoproteins play important role in the life cycle of coronaviruses. The assessment of their quantities is of general interest for the assembly of virions and medical applications. The proliferating nucleoproteins induce the related (auto)immune response and via binding to host RNA affect various regulation mechanisms. In this report we briefly summarize and comment the available experimental data on the subject concerned.