UnfoldML: Cost-Aware and Uncertainty-Based Dynamic 2D Prediction for Multi-Stage Classification
Yanbo Xu, Alind Khare, Glenn Matlin, Monish Ramadoss, Rishikesan, Kamaleswaran, Chao Zhang, Alexey Tumanov

TL;DR
UnfoldML introduces a cost-aware, uncertainty-based framework for multi-stage classification that significantly reduces inference costs and enables early predictions, maintaining high accuracy across clinical and image classification tasks.
Contribution
It proposes a novel unfolding approach that transforms a monolithic classifier into a cascade of stage-specific classifiers, optimizing the accuracy-cost tradeoff.
Findings
Achieves 20X cost reduction in clinical disease prediction with 0.1% accuracy loss.
Enables early disease onset detection 3.5 hours sooner.
Reduces image classification costs by 5X with minimal accuracy decrease.
Abstract
Machine Learning (ML) research has focused on maximizing the accuracy of predictive tasks. ML models, however, are increasingly more complex, resource intensive, and costlier to deploy in resource-constrained environments. These issues are exacerbated for prediction tasks with sequential classification on progressively transitioned stages with ''happens-before'' relation between them.We argue that it is possible to ''unfold'' a monolithic single multi-class classifier, typically trained for all stages using all data, into a series of single-stage classifiers. Each single-stage classifier can be cascaded gradually from cheaper to more expensive binary classifiers that are trained using only the necessary data modalities or features required for that stage. UnfoldML is a cost-aware and uncertainty-based dynamic 2D prediction pipeline for multi-stage classification that enables (1)…
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Taxonomy
TopicsMachine Learning in Healthcare · AI in cancer detection · COVID-19 diagnosis using AI
