Close contact restriction periods for patients who received iodine-131 therapy for differentiated thyroid cancer

TL;DR

This study compares a new computer program called Dorn with an existing spreadsheet for calculating contact restriction periods after iodine-131 therapy, showing Dorn provides more accurate and potentially shorter restrictions, improving safety and compliance.

Contribution

The paper introduces Dorn, a computer program that improves restriction period calculations by eliminating approximation errors present in the traditional spreadsheet.

Findings

Dorn often suggests shorter restriction periods, enhancing patient convenience.

In some cases, Dorn indicates longer restrictions, ensuring safety.

Dorn's calculations are more accurate and reliable.

Abstract

Objective. Patients treated with radionuclide therapy may require restrictions on certain activities for a period of time following treatment to optimise protection of the public and ensure the legal dose limit is not exceeded. Software may be used to calculate necessary restriction periods for an individual based on longitudinal dose rate measurements from the time of radiopharmaceutical administration. A spreadsheet program has been used for this purpose in Australian hospitals for the last two decades. However, this spreadsheet has a limitation in that it uses an approximation in the calculation of dose from a contact pattern, which affects the calculated restriction period. A computer program called Dorn was developed that provides the same functionality as the spreadsheet but without this approximation. Proffered radiation safety advice from Dorn and the spreadsheet were compared. Approach. Advice from the spreadsheet and Dorn were compared for 55 patients who underwent iodine-131 therapy for differentiated thyroid cancer. Main results. The restriction periods for caring for infants, close contact with children and sleeping with a partner were typically about 13 hours longer in Dorn than in the spreadsheet, but in some cases were over a week shorter or a month longer. Significance. If the Dorn program is used clinically in place of the spreadsheet, some patients will enjoy shorter restriction periods and the therapy provider can be more confident in their compliance with regulatory requirements and best practice. Dorn is freely available from https://doi.org/jg5f.