Electrostatic Catalysis of a Click Reaction in a Microfluidic Cell

TL;DR

This paper demonstrates a scalable electrostatic catalysis method for a click reaction within a microfluidic device, showing enhanced reagent transport and reaction efficiency compared to traditional methods.

Contribution

It introduces a novel large-area electrostatic microfluidic reactor that enables controlled, scalable electrostatic catalysis of a Huisgen cycloaddition reaction.

Findings

Enhanced reagent transport in the microfluidic setup.

Electrostatic catalysis achieves comparable or improved reaction rates.

Scalable continuous-flow platform demonstrated for large-area electrodes.

Abstract

Electric fields have been highlighted as a smart reagent in nature's enzymatic machinery, as they can directly trigger or accelerate redox and/or non-redox chemical processes with stereo- and regio-specificity. In natural catalysis, controlled mass transport of chemical species in confined spaces is also key in facilitating the transport of reactants into the active reaction site. Despite the opportunities the above offers in developing strategies for a new, clean electrostatic catalysis exploiting oriented electric fields, research in this area has been mostly limited to theoretical and experimental studies at the level of single molecules or small molecular ensembles, where both the control over mass transport and scalability cannot be tested. Here, we quantify the electrostatic catalysis of a prototypical Huisgen cycloaddition in a large-area electrode surface and directly compare its performance to the traditional Cu(I)-catalyzed method of the same reaction. Mass diffusion control is achieved in a custom-built microfluidic cell, which enhances reagent transport towards the electrified reactive interface while avoiding both turbulent flow conditions and poor control of the convective mass transport. This unprecedented electrostatic continuous-flow microfluidic reactor is an example of an electric-field driven platform where clean large-scale electrostatic catalytic processes can be efficiently implemented and regulated.