Prediction of Cross-Fitness for Adaptive Evolution to Different Environmental Conditions: Consequence of Phenotypic Dimensional Reduction

TL;DR

This paper develops a theoretical framework linking phenotypic dimensional reduction to cross-fitness prediction, enabling anticipation of evolutionary responses to various stresses based on transcriptome data.

Contribution

It introduces a theoretical model connecting high-dimensional phenotypic changes to cross-resistance, advancing understanding of adaptive evolution prediction.

Findings

Correlation between fitness change and transcriptome response established

Theoretical relationship predicts evolution based on transcriptome data

Framework applicable to microbiological evolution experiments

Abstract

How adaptive evolution to one environmental stress improves or suppresses adaptation to another is an important problem in evolutionary biology. For instance, in microbiology, the evolution of bacteria to be resistant to different antibiotics is a critical issue that has been investigated as cross-resistance. In fact, recent experiments on bacteria have suggested that the cross-resistance of their evolution to various stressful environments can be predicted by the changes to their transcriptome upon application of stress. However, there are no studies so far that explain a possible theoretical relationship between cross-resistance and changes in the transcriptome, which causes high-dimensional changes to cell phenotype. Here, we show that a correlation exists between fitness change in stress tolerance evolution and response to the environment, using a cellular model with a high-dimensional phenotype and establishing the relationship theoretically. The present results allow for the prediction of evolution from transcriptome information in response to different stresses before evolution. The relevance of this to microbiological evolution experiments is discussed.