Measurement of the time structure of FLASH beams using prompt gamma rays and secondary neutrons as surrogates

TL;DR

This study demonstrates that pixelated semiconductor detectors can accurately monitor irradiation and scan times in FLASH radiotherapy using prompt gamma rays and secondary neutrons, enabling real-time treatment verification.

Contribution

It introduces the use of fast spectral detectors for online monitoring of FLASH beam time structure, showing high accuracy in vivo and in different irradiation scenarios.

Findings

AdvaPIX-TPX3 measures IRTs within 1% accuracy.

Prompt gamma rays are effective surrogates for primary protons.

Scan times are faster in Y-direction than in X-direction.

Abstract

We aim to investigate the feasibility of online monitoring of irradiation time (IRT) and scan time for FLASH radiotherapy using a pixelated semiconductor detector. Measurements of the time structure of FLASH irradiations were performed using fast, pixelated spectral detectors, AdvaPIX-TPX3 and Minipix-TPX3. The latter has a fraction of its sensor coated with a neutron sensitive material. With little or no dead time and an ability to resolve events that are closely spaced in time (tens of ns), both detectors can accurately determine IRTs as long as pile-ups are avoided. To avoid pile-ups, we placed the detectors beyond the Bragg peak or at a large scattering angle. We acquired prompt gamma rays and secondary neutrons and calculated IRTs based on timestamps of the first (beam-on) and the last (beam-off) charged species. We also measured scan times in x, y, and diagonal directions. We performed these measurements for a single spot, a small animal field, a patient field, and a ridge filter optimized field to demonstrate in vivo online monitoring of IRT. All measurements were compared to vendor log files. Differences between measurements and log files for a single spot, a small animal field, and a patient field were within 1%, 0.3% and 1%, respectively. In vivo monitoring of IRTs was accurate within 0.1% for AdvaPIX-TPX3 and within 6.1% for Minipix-TPX3. The scan times in x, y, and diagonal directions were 4.0, 3.4, and 4.0 ms, respectively. Overall, the AdvaPIX-TPX3 can measure FLASH IRTs within 1% accuracy, indicating that prompt gamma rays are a good surrogate for primary protons. The Minipix-TPX3 showed a higher discrepancy, suggesting a need for further investigation. The scan times (3.4 \pm 0.05 ms) in the 60-mm distance of y-direction were less than (4.0 \pm 0.06 ms) in the 24-mm distance of x-direction, confirming the much faster scanning speed of the Y magnets than that of X.