Artificial intelligence-based locoregional markers of brain peritumoral microenvironment

TL;DR

This study introduces AI-derived markers based on diffusion imaging to quantify tumor infiltration heterogeneity in brain tumors, aiding prognosis and molecular classification.

Contribution

The paper presents a novel deep learning-based peritumoral microenvironment index (PMI) derived from DTI data, providing new biomarkers for tumor infiltration assessment.

Findings

Markers correlate with survival outcomes in glioma patients.

PMI distinguishes between IDH1-wildtype and mutant gliomas.

Markers reflect underlying tumor microstructural heterogeneity.

Abstract

In malignant primary brain tumors, cancer cells infiltrate into the peritumoral brain structures which results in inevitable recurrence. Quantitative assessment of infiltrative heterogeneity in the peritumoral region, the area where biopsy or resection can be hazardous, is important for clinical decision making. Previous work on characterizing the infiltrative heterogeneity in the peritumoral region used various imaging modalities, but information of extracellular free water movement restriction has been limitedly explored. Here, we derive a unique set of Artificial Intelligence (AI)-based markers capturing the heterogeneity of tumor infiltration, by characterizing free water movement restriction in the peritumoral region using Diffusion Tensor Imaging (DTI)-based free water volume fraction maps. A novel voxel-wise deep learning-based peritumoral microenvironment index (PMI) is first extracted by leveraging the widely different water diffusivity properties of glioblastomas and brain metastases as regions with and without infiltrations in the peritumoral tissue. Descriptive characteristics of locoregional hubs of uniformly high PMI values are extracted as AI-based markers to capture distinct aspects of infiltrative heterogeneity. The proposed markers are applied to two clinical use cases on an independent population of 275 adult-type diffuse gliomas (CNS WHO grade 4), analyzing the duration of survival among Isocitrate-Dehydrogenase 1 (IDH1)-wildtypes and the differences with IDH1-mutants. Our findings provide a panel of markers as surrogates of infiltration that captures unique insight about underlying biology of peritumoral microstructural heterogeneity, establishing them as biomarkers of prognosis pertaining to survival and molecular stratification, with potential applicability in clinical decision making.