Wall shear stress and pressure patterns in aortic stenosis patients with and without aortic dilation captured by high-performance image-based computational fluid dynamics

TL;DR

This study uses high-performance computational fluid dynamics to analyze wall shear stress and pressure patterns in aortic stenosis patients, revealing differences between those with and without aortic dilation and their potential role in disease progression.

Contribution

The paper introduces a GPU-accelerated, patient-specific CFD framework to analyze hemodynamic patterns in aortic stenosis, highlighting the impact of aortic dilation and arch branching on stress distributions.

Findings

Focal high wall shear stress and pressure are linked to aortic dilation.

Dilation cases show persistent high-pressure pockets, unlike non-dilation cases.

Proximal arch branching influences flow impingement and stress distribution.

Abstract

Spatial patterns of elevated wall shear stress and pressure due to blood flow past aortic stenosis (AS) are studied using GPU-accelerated patient-specific computational fluid dynamics. Three cases of moderate AS, one with a dilated ascending aorta and two within the normal range (root diameter less than 4cm) are simulated for physiological beat cycle waveforms obtained from echocardiography data. The computational framework is built based on sharp-interface Immersed Boundary Method, where aortic geometries segmented from CT angiograms are integrated into a high-order incompressible Navier-Stokes solver. We show that even though the wall shear stress is elevated and oscillatory due to turbulence in the ascending aorta for all the cases, its spatial distribution is significantly more focused for the case with dilation than those without dilation. This focal area is linked to aortic valve jet impingement on the outer curvature of the ascending aorta, and has been shown in vivo using 4D flow MRI of aortic stenosis patients with aortic dilation (van Ooij et al., J. Am. Heart Assoc., 6(9), 2017). We show that this focal area also accommodates a persistent pocket of high pressure, which is likely to have contributed to the dilation process through an increased wall-normal forcing. The cases without dilation, on the contrary, showed a rather oscillatory pressure behaviour, with no persistent pressure buildup effect. We further argue that a more proximal branching of the aortic arch could explain the lack of a focal area of elevated wall shear stress and pressure, because it interferes with the impingement process due to fluid suction effects. These phenomena are further illustrated using an idealized aortic geometry. We finally show that a restored inflow condition eliminates the focal area of elevated wall shear stress and pressure zone from the ascending aorta.