Deep Learning for Classification of Thyroid Nodules on Ultrasound: Validation on an Independent Dataset

TL;DR

This study validates a deep learning algorithm for thyroid nodule classification on ultrasound across different datasets, showing performance comparable to experienced radiologists regardless of ultrasound machine differences.

Contribution

The paper demonstrates the generalizability of a deep learning model for thyroid nodule classification on ultrasound from a previous dataset to a new, independent dataset from different ultrasound machines.

Findings

Deep learning algorithm achieved an AUC of 0.69.

Radiologists' AUC ranged from 0.63 to 0.66.

Performance was consistent across different ultrasound scanners.

Abstract

Objectives: The purpose is to apply a previously validated deep learning algorithm to a new thyroid nodule ultrasound image dataset and compare its performances with radiologists. Methods: Prior study presented an algorithm which is able to detect thyroid nodules and then make malignancy classifications with two ultrasound images. A multi-task deep convolutional neural network was trained from 1278 nodules and originally tested with 99 separate nodules. The results were comparable with that of radiologists. The algorithm was further tested with 378 nodules imaged with ultrasound machines from different manufacturers and product types than the training cases. Four experienced radiologists were requested to evaluate the nodules for comparison with deep learning. Results: The Area Under Curve (AUC) of the deep learning algorithm and four radiologists were calculated with parametric, binormal estimation. For the deep learning algorithm, the AUC was 0.69 (95% CI: 0.64 - 0.75). The AUC of radiologists were 0.63 (95% CI: 0.59 - 0.67), 0.66 (95% CI:0.61 - 0.71), 0.65 (95% CI: 0.60 - 0.70), and 0.63 (95%CI: 0.58 - 0.67). Conclusion: In the new testing dataset, the deep learning algorithm achieved similar performances with all four radiologists. The relative performance difference between the algorithm and the radiologists is not significantly affected by the difference of ultrasound scanner.