Long-Lived States of Methylene Protons in Achiral Molecules

TL;DR

This paper demonstrates that long-lived states of methylene protons can be efficiently excited in common achiral molecules using poly-SLIC, leading to significantly extended relaxation times, with potential applications in molecular analysis.

Contribution

It introduces a novel method to excite long-lived states in methylene protons of achiral molecules without isotopic enrichment or stereogenic centers.

Findings

LLS can be excited in various molecules including metabolites and amino acids.

Lifetimes T_{LLS} are 3 to 6 times longer than T_1.

Multiple molecules can be excited simultaneously.

Abstract

It is shown that long-lived states (LLS) involving pairs of methylene protons in nuclear magnetic resonance (NMR) can be readily excited in common molecules that contain two or more neighboring CH$_2$ groups. Accessing such LLS does not require any isotopic enrichment, nor does it require any stereogenic centers to lift the chemical equivalence of CH$_2$ protons. The excitation of LLS is achieved by polychromatic spinlock-induced crossing (poly-SLIC). In a variety of metabolites, neurotransmitters, vitamins, amino acids, and other molecules, LLS were created for the first time. One can excite LLS in several different molecules simultaneously. The lifetimes T$_{LLS}$ are typically 3 to 6 times longer than T$_1$.