Tunable intervalence charge transfer in ruthenium Prussian blue analogue enables stable and efficient biocompatible artificial synapses

TL;DR

This paper introduces ruthenium Prussian blue analogue as a stable, efficient, and biocompatible material for artificial synapses, demonstrating tunable conductance, improved retention, and potential for brain-computer interfaces.

Contribution

It presents a novel RuPBA material with electrochemically tunable oxidation states enabling reversible conductance switching for artificial synapses.

Findings

Conductance can be switched by over four orders of magnitude.

Retention of programmed states is significantly improved.

Demonstrated dopamine detection and biocompatibility with neuronal cells.

Abstract

Emerging concepts for neuromorphic computing, bioelectronics, and brain-computer interfacing inspire new research avenues aimed at understanding the relationship between oxidation state and conductivity in unexplored materials. Here, we present ruthenium Prussian blue analogue (RuPBA), a mixed valence coordination compound with an open framework structure and ability to conduct both ionic and electronic charge, for flexible artificial synapses that reversibly switch conductance by more than four orders of magnitude based on electrochemically tunable oxidation state. Retention of programmed states is improved by nearly two orders of magnitude compared to the extensively studied organic polymers, thus reducing the frequency, complexity and energy costs associated with error correction schemes. We demonstrate dopamine detection using RuPBA synapses and biocompatibility with neuronal cells, evoking prospective application for brain-computer interfacing. By application of electron transfer theory to in-situ spectroscopic probing of intervalence charge transfer, we elucidate a switching mechanism whereby the degree of mixed valency between N-coordinated Ru sites controls the carrier concentration and mobility, as supported by DFT.