Does the greater power of pencil beam scanning reduce the need for a proton gantry? A study of head-and-neck and brain tumors

TL;DR

This study demonstrates that pencil beam scanning proton therapy can produce high-quality treatment plans for head-and-neck and brain tumors without a gantry, potentially enabling more compact and accessible proton therapy systems.

Contribution

The paper shows that high-quality proton therapy plans are achievable without a gantry using pencil beam scanning and upright patient positioning, expanding possibilities for more compact treatment systems.

Findings

Gantry-less plans had similar target homogeneity and organ dose as gantry plans.

Robustness to setup errors and range uncertainties was comparable between plans.

Feasibility of upright patient positioning for proton therapy was supported.

Abstract

Proton therapy systems without a gantry can be more compact and less expensive in terms of capital cost, and therefore more available to a larger patient population. Would the advances in pencil beam scanning and robotics make gantry-less treatment possible? In this study, we explore if high-quality treatment plans can be obtained without a gantry. We recently showed that proton treatments with the patient in an upright position may be feasible with a new soft robotic immobilization device and imaging which enables multiple possible patient orientations during a treatment. In this study, we evaluate if this new treatment geometry could enable high quality treatment plans without a gantry. We created pencil beam scanning (PBS) treatment plans for seven patients with head-and-neck or brain tumors. Each patient was planned with two scenarios: one with a gantry with the patient in supine position and the other with a gantry-less fixed horizontal beam-line with the patient sitting upright. For the treatment plans, dose-volume-histograms (DVHs), target homogeneity index (HI), mean dose, D_2 and D_98 are reported. A robustness analysis of one plan was performed with +/-2.5 mm setup errors and +/-3.5% range uncertainties with nine scenarios. Most of the PBS-gantry-less plans had similar target HI and OAR mean dose as compared to PBS-gantry plans, and similar robustness with respect to range uncertainties and setup errors. Pencil beam scanning provides sufficient power to deliver high quality treatment plans without requiring a gantry for head-and-neck or brain tumors. In combination with the development of the new positioning and immobilization methods required to support this treatment geometry, this work suggests the feasibility of further development of a compact proton therapy system with a fixed horizontal beam-line to treat patients in sitting and reclined positions.