Predicting regrowth of low-grade gliomas after radiotherapy

TL;DR

This study develops a simple analytical model to predict the regrowth time of low-grade gliomas after radiotherapy using limited early post-treatment data, enabling personalized follow-up planning.

Contribution

The paper introduces a robust four-parameter model and a statistical constraint to estimate tumour regrowth time shortly after radiotherapy, even with few measurements.

Findings

Predicted regrowth time with 6 months precision at first MRI post-RT.

Achieved 75% reliable estimates of regrowth time, especially for fast-responders.

Feasibility demonstrated for personalized regrowth predictions shortly after treatment.

Abstract

Diffuse low grade gliomas are invasive and incurable brain tumours that inevitably transform into higher grade ones. A classical treatment to delay this transition is radiotherapy (RT). Following RT, the tumour gradually shrinks during a period of typically 6 months to 4 years before regrowing. To improve the patient's health-related quality of life and help clinicians build personalised follow-ups, one would benefit from predictions of the time during which the tumour is expected to decrease. The challenge is to provide a reliable estimate of this regrowth time shortly after RT (i.e. with few data), although patients react differently to the treatment. To this end, we analyse the tumour size dynamics from a batch of 20 high-quality longitudinal data, and propose a simple and robust analytical model, with just 4 parameters. From the study of their correlations, we build a statistical constraint that helps determine the regrowth time even for patients for which we have only a few measurements of the tumour size. We validate the procedure on the data and predict the regrowth time at the moment of the first MRI after RT, with precision of, typically, 6 months. Using virtual patients, we study whether some forecast is still possible just three months after RT. We obtain some reliable estimates of the regrowth time in 75\% of the cases, in particular for all "fast-responders". The remaining 25\% represent cases where the actual regrowth time is large and can be safely estimated with another measurement a year later. These results show the feasibility of making personalised predictions of the tumour regrowth time shortly after RT.