Estimating Particle Size for Therapeutic Application of Boron in Proton Therapy using the Finite Element Method

TL;DR

This paper uses finite element simulations to determine the optimal boron particle size, specifically 1.3 nm radius, for enhancing radiation dose in proton therapy, aiming to improve tumor targeting.

Contribution

It introduces a simulation-based method to identify the optimal boron particle size for dose enhancement in proton therapy, focusing on particle size effects on radiation output.

Findings

Optimal boron particle radius is 1.3 nm for maximum alpha particle output.

Maximum dose enhancement depends on biological system limitations.

Simulations compare energy outputs for different particle sizes.

Abstract

Previous measurements have shown large cross sections for the 11B(p,$\alpha$)8Be reaction and K-shell ionization of boron from H+ ions. Past publications have shown that this reaction will likely increase the efficacy of proton therapy. This study investigates the size of boron particles for optimum treatment enhancement in proton therapy. Simulations of protons passing through varying sized boron particles were developed to compare energy outputs for alpha particles and low energy electrons. The results for the boron particle radius that produced the largest radiation output are presented in graphical form in this paper. The radius that produced the largest Auger output was determined to be 1.3 nm. The results indicate that maximum dose enhancement will depend on the limiting factors of the biological system in regards to the appropriately sized particle. Studying different reactions that may be applied in hadron therapies allows researchers and physicians to target tumor sites more selectively.