Stochastic mRNA production by a three-state gene

TL;DR

This paper introduces a stochastic three-state gene model to analyze mRNA production, incorporating gene state transitions and mRNA degradation, providing insights into gene expression variability.

Contribution

It develops a novel three-state stochastic model for gene regulation, capturing the dynamics of gene activation, mRNA synthesis, and degradation.

Findings

Analytical expressions for mRNA distribution derived.

Insights into how gene state transitions affect mRNA variability.

Potential applications in understanding gene expression noise.

Abstract

We consider a model of mRNA production governed by the dynamics of a gene that exists in three possible states -- inactive, poised and active. The transitions between the adjacent states are controlled by stochastic processes characterized by corresponding on/off rates. mRNA is produced only when the gene is in active state and we also consider mRNA denaturation leading to its death.